The Relative Effects of Olmesartan Medoxomil, Irbesartan and Valsartan on the Activity of the Blood Pressure Control System in Healthy Subjects

Daiichi Sankyo20 enrolled

Overview

To assess the effects of 3 blood pressure drugs, called angiotensin receptor blockers, on the blood pressure control systems in healthy subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

Olmesartan medoxomilDRUG

IrbesartanDRUG

ValsartanDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women between the ages of 18 to 65 * In good health Exclusion Criteria: * Any serious health problems * Positive test for HIV, Hepatitis B and C * History of drug and alcohol abuse

Outcomes

Primary Outcomes

To characterize the plasma renin activity (PRA) and urinary aldosterone response patterns to single doses of olmesartan medoxomil, irbesartan, and valsartan compared to placebo in normal volunteers.

Data from ClinicalTrials.gov

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