Study of Co-administration of Olmesartan Medoxomil Plus Amlodipine in Patients With Mild to Severe Hypertension

Daiichi Sankyo1,900 enrolled

Overview

This study assesses the efficacy and safety of co-administration of olmesartan medoxomil plus amlodipine in mild to severe hypertensive patients older than 18 years of age

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

1,900

Conditions

Hypertension

Interventions

Olmesartan medoxomilDRUG

AmlodipineDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female patients * 18 years of age or older (20% equal to or older than 65 years) * With mild to severe hypertension defined as seated diastolic blood pressure of 95-120 mmHg while off any hypertensive medication Exclusion Criteria: * Patients should not have serious concomitant conditions that could interfere with the analysis of the results or that could interfere with the well-being of the patients

Locations (139)

Outcomes

Primary Outcomes

Change from baseline in trough seated systolic blood pressure and seated diastolic blood pressure for each treatment arm

Secondary Outcomes

To evaluate the number (%) of patients achieving BP goal.

To characterize the pharmacokinetic interactions and the corresponding pharmacodynamic (BP) correlation

Data from ClinicalTrials.gov

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Unnamed facility

Birmingham, Alabama, United States

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Huntsville, Alabama, United States

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Mobile, Alabama, United States

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Muscle Shoals, Alabama, United States

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Tuscumbia, Alabama, United States

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Little Rock, Arkansas, United States

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Anaheim, California, United States

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Beverly Hills, California, United States

...and 129 more locations