The Use of Prophylactic Antibiotics In the Management of Dog Bites

Stanford University125 enrolled

Overview

This double blinded RCT will help to ascertain the usefulness of prophylactic antibiotics in the management of uncomplicated dog bites, utilizing currently best available antibiotics (Augmentin) and an important clinical outcome of infection. By enrolling 100-150 patients in this pilot trial as part of a k-award the investigators plan to utilize the point estimates of infection, side effects and other important outcomes and incorporate these into a cost most to determine the most cost effective management of these wounds and to determine if further study is warranted based on the findings.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

125

Conditions

Bite Wound

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: All patients including all children and English speaking/reading persons who present with a full thickness dog bite to participating emergency departments will be considered. Non-English speaking/reading subjects for whom we can provide translation for will also be considered. Exclusion Criteria: Exclusion Criteria: * allergy to penicillin or amoxicillin/clavulanic acid * wounds presenting with an active infection (require antibiotics) or greater than 12 hours old. * patients with underlying fracture, joint or neurovascular injury, or multiple trauma requiring specialty referral. Specifically any broken skin over a joint will need treatment and be excluded from the study and randomization. * patients on immunosuppressive agents, prolonged chronic steroid use (defined as continuous use for \> 14 days, 3 times a year) active HIV disease (determined by treating physician on history) or splenectomized. (could skew one group and at risk for overwhelming sepsis and death if infected) * patients unwilling or unable to complete the required follow-up, and those unable to provide a contact phone number

Locations (3)

Mills Peninsula Hospital

Burlingame, California, United States

UCSF Medical Center

San Francisco, California, United States

Stanford University Medical Center

Stanford, California, United States

The Use of Prophylactic Antibiotics In the Management of Dog Bites

Overview

Conditions

Interventions

Eligibility

Locations (3)

Outcomes

Primary Outcomes

Secondary Outcomes