Comparison of Once Daily Versus 8 Hour Dosing of Gentamicin for the Treatment of Intrapartum Chorioamnionitis

N/ACompletedNCT00185991

Stanford University126 enrolled

Overview

To compare once daily versus 8 hour dosing of gentamicin for the treatment of chorioamnionitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

126

Conditions

Chorioamnionitis

Interventions

gentamicinDRUG

Daily gentamicin (5 mg/kg intravenously, then placebo doses IV after 8 and 16 hours). Eight hour gentamicin (2 mg/kg intravenously, then 1.5 mg/kg IV after 8 and 16 hours).

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- clinical diagnosis of chorioamnionitis Exclusion Criteria: \- maternal renal disease, intrauterine fetal death, allergy to gentamicin

Locations (1)

Stanford University School of Medicine

Stanford, California, United States

Outcomes

Primary Outcomes

Afebrile at 24 hours and no endometritis

Time frame: 24 hours after delivery

Secondary Outcomes

Neonatal outcomes

Time frame: Time of delivery to time of discharge

Data from ClinicalTrials.gov

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