Stem Cell Transplant From Matched Unrelated or Partially Matched Related Donors

Stanford University250 enrolled

Overview

To evaluate the use of unrelated donors for hematopoietic cell transplantation in the treatment of hematologic and lymphoid malignancies.

Stem Cell Transplantation from Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY). To administer high dose radio-chemotherapy followed by stem cell transplantation from a matched unrelated donor or a partially matched related donor.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

250

Conditions

Blood Cancer Blood and Marrow Transplant (BMT)

Interventions

ablative allogeneic hematopoietic cell transplantationPROCEDURE

Eligibility

Sex: ALLMin age: 4 WeeksMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria:- acute leukemia * chronic leukemia * lymphoblastic lymphoma * MDS * MPS Exclusion Criteria:- organ dysfunction * HIV positive

Locations (1)

Stanford University School of Medicine

Stanford, California, United States

Outcomes

Primary Outcomes

oxicity and efficacy of TBI and cyclophosphamide as preparation for hematopoietic cell transplantation from partially matched and unrelated donors.

Secondary Outcomes

Overall Survival

Event Free Survival

Data from ClinicalTrials.gov

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