A Longitudinal Study of Plasma EBV DNA in Nasopharyngeal Carcinoma From Both Endemic and Non-Endemic Patient Populations

Stanford University49 enrolled

Overview

1. To determine the prognostic implication of plasma Epstein-Bar Virus (EBV) DNA concentrations, as measured by quantitative polymerase chain reaction (PCR) in patients with nasopharyngeal carcinoma (NPC). 2. To relate pretreatment plasma EBV DNA concentration to WHO classification of these tumors both in endemic and non-endemic areas. 3. To determine whether pretreatment plasma EBV DNA can serve as a prognostic factor for both endemic and non-endemic patient populations.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mouth Cancer Lip Cancer Throat Cancer Lip Neoplasms Head and Neck Cancers

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Having a new diagnosis of Nasopharyngeal carcinoma. * Being treated with either radiotherapy or chemoradiotherapy for this condition. Exclusion Criteria: * Age \<18 since NPC is a very rare condition in this age group and may have a different biological behavior * Patients who are unable to provide informed consents for themselves.

Outcomes

Primary Outcomes

Plasma Epstein-Bar Virus (EBV) DNA concentrations

measured by quantitative polymerase chain reaction (PCR)

Time frame: every 6 months until end of study