Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression. In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.
Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
21
treatment for 10 days
St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street
Hamilton, Ontario, Canada
Hamilton Depression Rating Scale
Time frame: Pre TMS and post TMS
Beck Depression Rating Scale
Time frame: pre TMS and post TMS
Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow
Time frame: pre TMS and post TMS as well as post phase II, second set of TMS
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.