IMRT Lower Limb Soft Tissue Sarcoma

University Health Network, Toronto59 enrolled

Overview

Intensity-modulated radiation therapy may make wound healing problems less likely by 1)precisely shaping the region of high radiation dose to the shape of the tissue which harbours tumour cells, and 2) precisely shaping the regions of low radiation dose to the shapes of the normal tissues which are more sensitive to radiation effects.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Sarcoma

Interventions

Intensity Modulated Radiation TherapyRADIATION

Pre-op Intensity Modulated Radiation Therapy for lower limb soft tissue sarcoma.

Eligibility

Sex: ALLMin age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Histologically proven soft tissue sarcoma * Lesion lies between the iliac crest (hipbone) and the ankle * Lesion is newly diagnosed * Assessed by radiation oncologist and surgical oncologist Exclusion Criteria: * Benign histologies * Histologies generally treated with chemotherapy * Prior or recurrent cancer, except nonmelanomatous skin cancer or carcinoma in-situ of the cervix

Locations (1)

Princess Margaret Hospital

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

Major wound complications within 120 days following surgery

Time frame: 120 days post-op

Secondary Outcomes

Assess acute and late radiation toxicity including limb edema

Time frame: up to120 days

Data from ClinicalTrials.gov

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