Xray Volume Imaging (Cone Beam CT) - Prostate Cancer

University Health Network, Toronto30 enrolled

Overview

Conformal dose escalated radiotherapy was adopted as the standard treatment technique at PMH for intermediate risk patients with localised disease in 1997. This technique provides a much smaller margin of error for treatment set-up and delivery than with conventional techniques. One way to ensure the accuracy of treatment delivery is to image the prostate position daily, prior to therapy, to allow for appropriate set-up corrections. To do so, imaging markers are implanted into the prostate under guided ultrasound (a standard procedure at PMH). However, there are disadvantages in using imaging markers which include added time to the treatment planning process, and an invasive procedure with a potential for discomfort, bleeding and infection. This study will investigate and compare X-ray volume imaging to the gold standard imaging markers.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Prostatic Neoplasms

Interventions

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of adenocarcinoma of the prostate * Patient undergoing escalated dose conformal external beam radiotherapy. * Patient has low or intermediate risk prognostic factors: all of PSA \<21, Gleason score \<8, clinical T category \<T3, clinical N category 0 or X, M category 0 or X. * Informed consent Exclusion Criteria: * No diagnosis of adenocarcinoma of the prostate * Patient not undergoing escalated dose conformal radiotherapy * Patient does not have low or intermediate risk prognostic factors

Outcomes

Primary Outcomes

To evaluate he feasibility of daily X-ray volume imaging during conformal radiotherapy.

Secondary Outcomes

To provide preliminary data concerning the relative utility of daily X-ray volume image matching compared to fiducial marker image matching.