Structured Treatment Interruption for HIV Patients With Virologic Failure

Inclusion Criteria: * Age \> 18 years. * On therapy with a triple ARV that includes a protease inhibitor and/or non-nucleoside reverse transcriptase inhibitor for the past 3 months with no changes in any agent of the combination in the past 14 days. * Virologic failure while on the combination as defined by a plasma HIV RNA \> 1000 copies/mL measured on 2 occasions at least 4 weeks apart. * HIV RNA \<500,000 copies/mL. * CD4 cell count must be \> 50/mm3 * Patients must not have a present history of opportunistic infections or acute illness requiring treatment within the preceding 30 days. * The patient has at least two new ARV available based on history, and at least two of these new agents will be included in the new salvage regimen. Exclusion Criteria: * Active substance abuse which would interfere with the patient's ability to participate in this trial, or declared non-compliance. * Pregnancy or breast feeding. * Patients with any of the following abnormal laboratory test results at screening:· Hemoglobin\<80 g/L, neutrophil count\<750 cells/mL, Platelet\<20,000 /mL· AST or ALT \> 5X Upper Limit of Normal (ULN)· Creatinine \> 250 umol/L * End stage organ disease * Patient with malignancy receiving systemic chemotherapy * Patient has need for immune modulators (interleukin, interferon, GMCSF etc) or prednisone. This excludes a short course of inhaled or oral steroids for asthma exacerbation)