Immune Dysfunction in Allergic Asthma

University of New Mexico18 enrolled

Overview

We are using anti-IgE to investigate the role of pulmonary mast cells in asthma.

Subjects with mild allergic asthma are examined before, immediately after and 2 months after a course of treatment with anti-IgE. The following are examined: Allergen skin tests, allergen induced asthma, peripheral blood basophils, pulmonary bronchial mucosal mast cells.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Asthma

Interventions

XolairDRUG

Patients are administered Xolair

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: Mild asthma, adults - Exclusion Criteria: children. on inhaled or systemic steroids \-

Locations (1)

UNM HSC

Albuquerque, New Mexico, United States

Outcomes

Primary Outcomes

Anti-KLH Antibody. This is Measured by ELISA and Expressed as ELISA Units Which Are Derived by Dilution of Serum Samples Until the Result Falls on a Linear Portion of the Response Curve. Final Values Are Derived From ELISA Units and the Serum Dilution

Asthma and control patients are immunized with KLH. Mean levels of anti-KLH antibody as described above. This is measured by ELISA and expressed as ELISA units which are derived by dilution of serum samples until the result falls on a linear portion of the response curve. Final values are derived from ELISA units and the serum dilution

Time frame: 6 months

Data from ClinicalTrials.gov

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