Assist Control Versus Pressure Support Modes for Domiciliary Noninvasive Ventilation in Chronic Respiratory Failure

Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche100 enrolled

Overview

Noninvasive ventilation is a therapeutic option in some patients with chronic respiratory failure. Patients usually ventilate during nightime with a domiciliary ventilator either in assist control or in pressure support mode. The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.

The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

100

Conditions

Chronic Respiratory Failure

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chronic respiratory failure * Clinical symptoms of chronic alveolar hypoventilation * PaCO2 ≥ 45 mmHg in case of restrictive pulmonary disorder or PaCO2 ≥ 55 mmHg in case or obstructive pulmonary disorder Exclusion Criteria: * Clinical exacerbation during the three previous weeks * Previous treatment by domiciliary non invasive ventilation * Previous treatment by non invasive ventilation for acute respiratory failure during the 3 previous months * Bronchiectasis * Duchenne muscular dystrophy * Amyotrophic lateral sclerosis

Assist Control Versus Pressure Support Modes for Domiciliary Noninvasive Ventilation in Chronic Respiratory Failure

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes