Study on Safety, Tolerability and Immunogenicity of an MVA Vaccine Administered to Healthy Subjects

Inclusion Criteria: * Healthy male subjects, aged 20 - 55 years * Signed informed consent Exclusion Criteria: * Prior vaccination against smallpox (study part I only) * Abnormalities suspicious of any underlying disease, detected at routine tests prior to study inclusion. * Any immune modifying therapy within 4 weeks prior to entry * Participation in any other investigating drug trial * Known allergy to a component which may be part of the vaccine * Allergic reaction or any other severe adverse effects experienced after previous smallpox vaccination (study Part II only)