Biomechanical Effects of Duloxetine on Bladder and Sphincter Muscle Function in Women in Pure Genuine Stress Incontinence

Compare the effects of duloxetine with that of placebo on measures of bladder emptying phase function derived from

non-instrumented and instrumented uroflowmetry studies

Percent change in Incontinent Episode Frequency (IEF) from baseline to endpoint

Subject-perceived improvement in their GSI as measured by the Patient Global Impressions-Improvement (PGI-I) questionnaire at endpoint

Compare duloxetine responders with duloxetine non-responders with respect to:

Baseline measures of urethral function

Outcome measures of urethral function

Outcome measures of emptying function

Vital signs, laboratory values and the occurrence of treatment-emergent adverse events

In the open-label extension:

Determine the effects of duloxetine six to seven months after initiation on measures of urethral function

Collect long-term data on the maintenance of effect of duloxetine in the treatment of GSI as measured by IEF, PGI-I, vital signs, laboratory values and the occurrence of treatment-emergent adverse events.