A Study Comparing Pemetrexed Plus Best Supportive Care Versus Best Supportive Care Alone in the Treatment of Mesothelioma

Inclusion Criteria: * Histologically proven diagnosis of mesothelioma of the pleura. * received only one prior systemic chemotherapy regimen for advanced or metastatic disease * Performance status of 70 or higher on the Karnofsky Performance Status Scale * Males or females at least 18 years of age * Adequate organ function Exclusion Criteria: * Active infection that in the opinion of the investigator would compromise the patient's ability to tolerate therapy * Pregnancy or breastfeeding * Brain metastasis * Prior treatment with Pemetrexed * Inability or unwillingness to take folic acid or vitamin B12 supplementation