Trial to Compare the Safety, Tolerability and Efficacy of Influenza Virus Vaccine, (CAIV-T) With Influenza Virus in Children With Asthma

Inclusion Criteria: * who are aged at least 6 years to 17 years of age at the time of enrollment; * with a clinical diagnosis of asthma by one of the following criteria: * An International Classification of Diseases, Ninth revision (ICD-9) code 493 AND ≥one prescription for asthma medication; * OR ≥one prescription for an inhaled beta-agonist and ≥one prescription for cromolyn; * OR ≥Five prescriptions for any asthma medication (adapted from Kramarz et al,2000 and Osborne et al., 1995)1,2; * asthma medication\* is being defined as: * inhaled and oral β -agonists * theophyllin * inhaled, oral and injected steroids * other unclassified asthma medication * antibiotics used for treatment of respiratory illness associated with a wheezing episode; * at least one asthma medication should have been administered in the last 12 months * who, if female and is post-menarche, has provided a negative pregnancy test prior to the study vaccination; * who have provided written informed consent (as appropriate and according to national guidelines) and whose parent(s)/legal guardian(s) have provided written informed consent after the nature of the study has been explained; * who, along with their parent(s)/legal guardian(s), will be available for duration of the trial; * who/whose parent(s)/legal guardian(s), can be reached by study staff for the post-vaccination contacts \[telephone, clinic or home visit\]. Exclusion Criteria: * who/whose parent(s)/legal guardian(s) are perceived to be unavailable or difficult to contact for evaluation or study visits during the study period; * with any serious chronic disease (e.g., with signs of cardiac or renal failure or severe malnutrition), including progressive neurological disease; * with Down's syndrome or other known cytogenetic disorders; * with a known or suspected disease of the immune system or those receiving immunosuppressive therapy, including systemic corticosteroids of a dose equivalent to a total of 20 mg/day or greater of prednisolone or equivalent, for more than 14 days duration until 2 weeks after corticosteroids have been discontinued 25; * who received any blood products, including immunoglobulin, in the period from six months prior to vaccination through to the conclusion of the study; * for whom there is intent to administer any other investigational vaccine or agent from one month prior to enrollment through to the conclusion of the study; * who have an immunosuppressed or an immunocompromised individual living in the same household; * who received any influenza vaccine in the 6 months prior to enrollment, or are anticipated to receive a non-study influenza vaccine after enrollment; * with a documented history of hypersensitivity to egg or egg protein or any other component of the CAIV-T or TIV; * who received aspirin (acetylsalicylic acid) or aspirin-containing products in the two weeks prior to enrollment or for which use is anticipated during the study; * with any medical conditions that in the opinion of the investigator might interfere with interpretation of the study results; Note: Pregnancy in any person who has regular contact with the subject is not a contraindication to the enrollment or ongoing participation of the subject in the study.