Docetaxel Followed by Doxorubicin Plus Cyclophosphamide for Node Positive or High-Risk Primary Breast Cancer

Inclusion Criteria: To be included in this study, you must meet the following criteria: * Histologically proven breast cancer * Females, age greater than 18 years * Ability to perform activites of daily living with minimal assistance * Normal cardiac function * Adequate bone marrow, liver and kidney * Signed informed consent prior to beginning specific protocol procedures Exclusion Criteria: You cannot participate in this study if any of the following apply to you: * Prior systemic anticancer therapy for breast cancer * Prior anthracycline or taxane based chemotherapy for any malignancy * Pregnant or breast-feeding women. * Pre-existing moderate to severe motor or sensory neurotoxicity * Other serious illness or medical condition Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.