Topotecan Plus Paclitaxel and Carboplatin in the Initial Treatment of Advanced Ovarian and Primary Peritoneal Carcinoma

Inclusion Criteria: To be included in this study, you must meet the following criteria: * Epithelial ovarian carcinoma or primary peritoneal carcinoma * Willing to consider second-look surgery to evaluate response if necessary * No previous treatment with chemotherapy or radiation therapy * Ability to perform activities of daily living with minimal assistance * Adequate bone marrow, liver and kidney function * Written informed consent Exclusion Criteria: You cannot participate in this study if any of the following apply to you: * Age \< 18 years * Brain metastases * Recent history of significant heart disease within 6 months * Other significant medical conditions Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.