Efficacy of Celecoxib vs Placebo to Prevent Pain in a Paced Walk

Phase 4CompletedNCT00194090

University Hospitals Cleveland Medical Center40 enrolled

Overview

A paced 20-minute walk is a reproducible model for acute pain in knee osteoarthritis

This is a randomizd, placbo-controlled, crossover trial comparing a single dose of celecoxib to placebo measuring the time to onset of acute pain in a paced 20-minute walk. 40 subjects will be enrolled

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Knee Osteoarthritis

Interventions

celecoxibDRUG

Eligibility

Sex: ALLMin age: 45 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: Knee osteoarthritis by ACR clinical criteria Pain of at least 40 mm by VAS at baseline \- Exclusion Criteria: Non-pregant, non-lactating Able to stop active arthritis medication for washout Cardiovascular risk factors Abnormal EKG -

Locations (1)

University Hospitals of Cleveland

Cleveland, Ohio, United States

Outcomes

Primary Outcomes

time to onset of severe pain

Secondary Outcomes

time to onset of moderate pain

Data from ClinicalTrials.gov

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