Study Evaluating TTI-237 in Advanced Malignant Solid Tumors

Phase 1TerminatedNCT00195247

Wyeth is now a wholly owned subsidiary of Pfizer45 enrolled

Overview

The purpose of this study is to evaluate the safety, tolerability, and maximum tolerated dose (MTD) of TTI-237 for the treatment of subjects with advanced malignant solid tumors.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Neoplasms

Interventions

TTI-237DRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Documented diagnosis of malignant solid tumor with measurable disease * Life expectancy of at least 12 weeks * ECOG performance status of 0, 1, or 2 Exclusion Criteria: * Recent major surgery, radiation therapy or anti-cancer treatment * History of any other prior malignancy within the last 5 years

Locations (3)

Unnamed facility

Scottsdale, Arizona, United States

Unnamed facility

Los Angeles, California, United States

Unnamed facility

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

Primary purpose is to address the safety and tolerability of TTI-237. Patient will be assessed on an ongoing basis during their participation on the trial.

Secondary Outcomes

Preliminary pharmacokinetics (cycle 1 only) and anti-tumor activity of TTI-237 (approximately every 8 weeks).

Data from ClinicalTrials.gov

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