The aim of this study is to compare the efficacy and tolerance of piperacillin-tazobactam versus piperacillin-tazobactam plus glycopeptide as initial empiric antibiotic treatment for fever in neutropenic patients. Study of consecutive cohorts(2). First the patients will be included in the monotherapy branch until completing the predicted number of cases. When this happens, the Coordinating Center will communicate it to the participant centers and from then the patients will be included in the combined therapy.
Study Type
OBSERVATIONAL
Enrollment
801
Unnamed facility
A Coruña, Spain
Unnamed facility
Alcalá de Henares, Spain
Unnamed facility
Alzira, Spain
Unnamed facility
Barcelona, Spain
Unnamed facility
Castellon, Spain
Unnamed facility
Madrid, Spain
Unnamed facility
Salamanca, Spain
Unnamed facility
Santa Cruz de Tenerife, Spain
Unnamed facility
Tarragona, Spain
Unnamed facility
Valencia, Spain
...and 2 more locations
- Clinical efficacy evaluation:72 and 96 hours after the initiation of empirical therapy (early evaluation) and at the completion of the therapeutic trial (overall valuation)
Time frame: 3 months
- Safety evaluation:during the empirical therapy
Microbiological evaluation:at the completion of the therapeutic trial (overall evaluation)
Time frame: 3 Months
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