Early Assessment of Anthracycline-induced Cardiotoxicity (CARDIOTOX)

N/ATerminatedNCT00195897

Centre Henri Becquerel6 enrolled

Overview

Anthracycline-based chemotherapy is a key point of the treatment of patients with Hodgkin's and non-Hodgkin's lymphomas. However, cumulative doses are limited by cardiotoxicity, resulting in a marked left ventricular function impairment that may lead to heart failure. The standard clinical approach to monitoring for anthracycline cardiotoxicity is based on cardiac function monitoring using echocardiography or radionuclide angiography. The aim of this study is to evaluate the usefulness of biochemical markers of cardiac injury (troponin and NT-proBNP) and structural changes on cardiac MR in predicting anthracycline cardiotoxicity.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lymphoma Heart Failure, Congestive

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Histologically proven lymphoma (Hodgkin's or non-Hodgkin's) * Age \> 18 y/o and \< 70 y/o * WHO score \< or = 2 * Life expectancy \> 6 mo * Left ventricular ejection fraction \> 50% * Informed consent Exclusion Criteria: * Previous chemotherapy using anthracyclines * History of radiation therapy * History of congestive heart failure * History of chronic renal insufficiency * Contra indication to MR examination * Atrial fibrillation and significant arrhythmia * Pregnancy

Early Assessment of Anthracycline-induced Cardiotoxicity (CARDIOTOX)

Overview

Conditions

Eligibility

Locations (2)