Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training

Phase 2CompletedNCT00196885

German Cancer Research Center60 enrolled

Overview

The purpose of the study is to tests the hypothesis, that N-acetylcysteine (a thiol-antioxidant)improves the exercise training effect on cancer patients that experience weight loss (cachexia) as assessed by muscle mass and function as well as histomorphology.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Gastrointestinal Neoplasms Bronchial Carcinoma Hodgkin Disease Non-Hodgkin Lymphoma Weight Loss

Interventions

N-acetylcysteineDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * gastrointestinal or bronchial cancer * weight loss of 10% within 6 months * sufficient mobility Exclusion Criteria: * severe pain, steroid therapy, severe internal, muscular, neurological, psychiatric disease, N-acetylcysteine allergy

Locations (1)

German Cancer Research Center, D020

Heidelberg, Baden-Wurttemberg, Germany

Outcomes

Primary Outcomes

muscle cross-sectional area, peak forces

Secondary Outcomes

muscle fiber composition (biopsy vastus lateralis muscle mRNA levels of cytokines, myostatin. Activity of Akt-dependent pathways

muscle 31Phospho-magnetic-resonance spectroscopy

Data from ClinicalTrials.gov

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