The purpose of this study is to analyze stored samples and data collected during the conduct of the study "A Trial of Vitamins in HIV Progression and Transmission" (HD32257). The aims are to examine the effect of vitamin supplementation on HIV infected women during pregnancy on a number of parameters in breastmilk.
The purpose of this study is to analyze stored samples and data collected during the conduct of the study "A Trial of Vitamins in HIV Progression and Transmission" (HD32257). The aims are to examine the effect of vitamin supplementation on HIV infected women during pregnancy
Study Type
OBSERVATIONAL
Enrollment
771
30 mg beta-carotene plus 5000 IU preformed vitamin A) taken orally once per during pregnancy and lactation
30 mg thiamine, 20 mg riboflavin, 20 mg B-6, 100 mg niacin, 50 ug vitamin B-12, 500 mg vitamin C, 30 mg vitamin E, 0.8 mg folic acid taken orally once per day during pregnancy and lactation
20 mg thiamine, 20 mg riboflavin, 25 mg vitamin B6, 100 mg niacin, 50 ug vitamin B12, 500 mg vitamin C, 30 mg vitamin E, and 0.8 mg folic acid taken once per day orally during pregnancy and lactation
Harvard School of Public Health
Boston, Massachusetts, United States
cell-free viral load and/or cell-associated proviral load in breast milk
Time frame: Delivery, 3 months, and 6 months after delivery
concentration of vitamins A, B12, and E in breast milk
Time frame: Delivery, 3 months, and 6 months post-delivery
subclinical mastitis
Time frame: Delivery, 3 months, and 6 months after delivery
post-natal mother-to-child transmission of HIV
Time frame: Delivery, 3 months, and 6 months post-delivery
infant mortality and morbidity from diarrhea
Time frame: Delivery, 3 months and 6 months after delivery
a.) CCR5 expression in differentiating monocytes and differentiated monocyte-derived macrophages
Time frame: N/A (in vitro experiment)
HIV-1 replication in differentiating monocytes acutely infected with a subtype C HIV-1 clone, differentiated non-dividing MDMs acutely infected with the HIV-1 MJ4 clone, and differentiated non-dividing MDMs chronically infected with the HIV-1 MJ4 clone.
Time frame: N/A (in vitro experiment)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Placebo pill taken orally once per day during pregnancy and lactation