Immunogenicity and Reactogenicity of a Meningococcal B Outer Membrane Vesicle Vaccine Given in a 0,6,12 Month Schedule to Health UK Adults

Inclusion Criteria: * Informed written consent given for three immunizations with MenBVac and five blood tests * Between the ages of 18 and 55 years inclusive at recruitment Exclusion Criteria: * Previous history of bacteriologically confirmed meningococcal disease * History of clinically significant allergic sensitivity to any vaccine received in the past * Immunodeficiency * Any other acute or chronic systemic illness or dependence or abuse of drugs or alcohol * Language difficulties sufficient to preclude adequate comprehension of the study information * Possibility of pregnancy * Receipt of any other vaccine in the previous 4 weeks * Receipt of any group B vaccine in the past * Current participation in any other clinical trial * Generalized acute systemic illness and/or temp \>38C on day of vaccination deferral