Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.

N/ACompletedNCT00197886

Herlev Hospital10 enrolled

Overview

Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells. This leads to increased formation of lactic acid. This study examines whether increasing the dose of norepinephrine leads to higher concentrations of lactic acid in the rectum and stomach in patients with life-threatening infection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Septic Shock

Interventions

Changing dose of norepinephrine and blood pressureDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Septic shock * NE-dose \> 0.1 microg/kg/min * CI \> 3.0 l/min/m2 Exclusion Criteria: * Age \< 18, unable to obtain informed consent from relatives * Untreated hypertension * Pregnancy * Pathology in the rectum or stomach * Limitation of therapy

Locations (1)

Dept. of Intensive Care, Herlev University Hospital

Herlev, Denmark

Outcomes

Primary Outcomes

L-lactate concentration in the rectum and stomach.

Data from ClinicalTrials.gov

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