Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage

Inclusion Criteria: * Severe vitreous hemorrhage that obscures visualization of the fundus on indirect ophthalmoscopy, that has been present \>/= 1 month by history or exam * BCVA is worse than 20/200 at time of screening Exclusion Criteria: * Corneal or lenticular abnormalities that preclude fundus observation * Ongoing ocular infection, inflammation or history of herpetic corneal lesion * Current or prior retinal detachment or retinal tears or breaks or intraocular tumor * More than 1 severe vitreous hemorrhage within 6 months * Previous vitrectomy for any reason * Hemorrhage is exclusively pre-retinal, or old \& organized * Prior Vitrase for intravitreal injection in either eye * No light perception in either eye at any time * Known contraindications to study medication * Sickle cell disease