Efficacy and Safety Study of Argatroban to Treat Heparin-Induced Thrombocytopenia

Inclusion Criteria: 1. Males of non-pregnant females \>=20 and \<=80 years of age 2. Those with the diagnosis of HIT or HITTS made by the following diagnostic criteria, or those who have positive results of HIT antibody * diagnostic criteria of HIT * a fall in platelet count to less than 100,000/μL or a 50% decrease in platelets after the initiation of heparin therapy with no apparent explanation other than HIT * diagnostic criteria of HITTS * those who met the diagnosis criteria of HIT * presence of an arterial or venous thrombosis documented by appropriate imaging technique (ultrasound, angiography etc.) or supported by clinical evidence such as a myocardial infarction, stroke, pulmonary embolism, or other clinical indications of vascular occlusion(absence of pulse, cold, cyanotic extremities, etc.) * patients with history of HIT/HITTS with positive test results (HIT antibody or platelet function test) could be enrolled without present thrombocytopenia 3. patients willing and able to give informed consent Exclusion Criteria: 1. any condition which in the investigator's opinion, contraindicated the use of argatroban or endangered the patient if he or she participated in this trial 2. clinically significant or uncontrolled endocrine, renal, pulmonary, gastrointestinal, or psychiatric disorder of sufficient severity that the investigator deemed antithrombotic therapy with argatroban to be contraindicated 3. unexplained aPTT\>200% of control at baseline 4. documented coagulation disorder or unexplained bleeding diathesis unrelated to HIT 5. lumbar puncture within the past 7 days 6. known clinical site of bleeding. Patients with a known site of clinical bleeding could be enrolled if the investigator deemed the risk of continued thrombosis outweighed the potential bleeding risk 7. serious liver disfunction 8. females of known or suspected pregnancy 9. breast feeding females 10. participation in other clinical drug trials within the past 30 days 11. history of hypersensitivity to argatroban 12. concomitant use of cimetidine 13. previous participation in this trial