The benefit of small doses of ketamine has been demonstrated for postoperative analgesia in adults but remains unproved in children. The investigators' purpose is to evaluate the effects of continuous intravenous small doses of ketamine versus placebo to improve the quality of postoperative analgesia in children (6 months to 6 years of age). Caudal anesthesia is performed for intraoperative analgesia and all children receive paracetamol, a non-steroidal anti-inflammatory and continuous intravenous nalbuphine.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
74
Nantes University Hospital
Nantes, France
RECRUITINGArea under the curve of pain scores (CHEOPS) measured
Time frame: every 2 hours during the first 24 hours after eyes open
Evaluation by the parents and nurses of the quality of analgesia with a visual analogue scale graded from 0 to 10
Time frame: at the 24th hour
Number of painful episodes requiring additional boluses of nalbuphine
Number of children requiring morphine after inefficiency of additional boluses of nalbuphine
Percentage of children with side effects related to injection of ketamine
Time to complete feeding
Percentage of children with nausea or vomiting
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