Anti-Proteinuric Response to ACEI, ARB and Diuretics Combination.

Phase 4TerminatedNCT00200694

Nantes University Hospital18 enrolled

Overview

Determine the best strategy for proteinuria lowering in patients with proteinuria \> 1 g/day receiving ACEI and ARB combination: either increase of ACEI and ARB dosage or increase of diuretic dosage.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Heavy Proteinuria

Interventions

ramipril 5 mg + valsartan 80 mg/day,DRUG

ramipril 10 mg + valsartan 160 mg/day,DRUG

ramipril 5 mg + valsartan 80 mg/day + increased dosage of furosémide.DRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * proteinuria \> 1 g/day with ramipril 5 + valsartan 80 mg/day for 2 months * proteinuria changes \< 50% on 3 separate dosages over 2 months. Exclusion criteria: * age \< 18 or \> 80 years systolic BP \< 110 or ≥ 140 mmHg, serum creatinine \> 250 mmole/L * serum creatinine increase on ramipril + valsartan \> 20% * intolerance to ACEI or ARB

Locations (1)

CHU de Nantes

Nantes, France

Data from ClinicalTrials.gov

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