A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria

Inclusion Criteria: * Male or female, older than 12 months. * Weight \> 10 kg. * Diagnoses of pure uncomplicated acute P. falciparum malaria parasitaemia of up to 500 000 asexual parasite/mcl blood with axillary temperature of greater than or equal to 37.5°C or history of fever (defined as within the previous 24 hours). * Documented informed consent. * Lives close enough to the study site for reliable follow up. Exclusion Criteria: * Has received anti-malarial treatment in the past 7 days. * Is infected with other malarial species (such subjects may be excluded retrospectively from the analysis). * Severely ill (based on WHO Criteria for severe malaria ) or if patient is considered, in the opinion of the investigator or designee, to have moderately severe malaria (e.g. prostrate, repeated vomiting, dehydrated) or other danger signs. * Has received cotrimoxazole, trimethoprim, chloramphenicol, folate or tetracyclines (including doxycycline) in the past 7 days or is likely to require these during the study period. * History of G6PD deficiency. * Is pregnant or breastfeeding. * Has a history of allergy to any of the study drugs (including other sulphonamides e.g. cotrimoxazole, other artemisinin derivatives e.g. co-artemether). * Serious underlying disease that in the opinion of the clinic team and/or Principal Investigator would make the patient unsuitable for the study in terms of their safety or study analysis.