Intralesional Treatment With Interleukin-2 (Proleukin) in Soft Tissue Melanoma Metastases

Inclusion Criteria: * Age 18+ * Informed consent * Histologically proven melanoma * Have confirmed stage IIIB or stage IV disease (AJCC 2002) with skin or soft-tissue metastases Exclusion Criteria: * Pregnant or lactating women * Patients with severe cardiac disease (e.g. NYHA Functional Class III or IV, myocardial infarction within 6 months, ventricular tachyarrhythmias requiring ongoing treatment, unstable angina) * Patients with severe liver disease or severe renal disease * Simultaneous immunosuppressive treatment (e.g. steroids) * Simultaneous chemotherapy * Pretreated soft-tissue or skin metastases (e.g. cryo-, radiotherapy)