Cardiac Water and Fluoromethane Cardiac PET

N/ACompletedNCT00205127

University of Wisconsin, Madison10 enrolled

Overview

In this study we are looking at the blood flow to the heart using two different chemical tags or tracers that give off a low level of radiation. The tracers used in this study are called O15-water and F17-fluoromethane. These tracers mix with the blood and will move through the body. The researchers will use positron emission tomography (PET scans)to track the tracers as they moe through the heart and chest.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Healthy Volunteers

Interventions

Cardiac PET imaging- rest and pharmacological stressPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 1\. Age 18 to 40 years old 2. Willing to provide written informed consent Exclusion Criteria: * 1\. A history of CAD 2. A history of active bronchospasm or asthma on theophylline bronchodilators 3. A history of any cardiac risk factors including: HTN, Diabetes, Hyperlipidemia, Smoking, and premature CAD in immediate family member 4. A history of liver disease or other significant disease 5. Females who are pregnant or lactating

Locations (1)

University of Wisconsin

Madison, Wisconsin, United States

Outcomes

Primary Outcomes

-- implement myocardial perfusion quantification for O15-labeled water at rest and with pharmacologic stress,

Time frame: assess at time of PET scan

-- determine the biodistribution of fluoromethane in the thorax to see if it is usable for a cardiac perfusion tracer,

Time frame: assess at time of PET Scan

Secondary Outcomes

--develop initial methods for quantification of myocardial perfusion if applicable for labeled fluoromethane.

Time frame: assess at time of PET scan

Data from ClinicalTrials.gov

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