Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?

N/ACompletedNCT00205166

University of Wisconsin, Madison50 enrolled

Overview

We are studying the affect of caffeine on the sensitivity of detecting coronary artery disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is a drug used routinely in patients to relax heart blood vessels in order to assess for the presence of coronary artery disease. Often, if patients have had caffeine, the adenosine scan is not used because of the belief that caffeine may reduce the ability to detect coronary artery disease. We would like to test whether caffeine affects our ability to detect coronary artery disease with adenosine tracer scanning. We will perform an imaging study of the heart with adenosine after you have received caffeine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Coronary Artery Disease

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who have already completed rest/stress 99mTc sestamibi or 99mTc tetrofosmin imaging will be given a form describing this protocol and asked to volunteer for the additional scan Exclusion Criteria: * history of asthma, bronchospastic COPD, or renal failure

Outcomes

Primary Outcomes

This protocol has a specific aim of determining whether prior caffeine administration affects the sensitivity and specificity of adenosine perfusion scintigraphy for detection of impaired coronary vascular reserve.

Time frame: Assessment is made at the time of research adenosine perfusion scintigraphy

Secondary Outcomes

determination of caffeine levels in patients instructed to hold caffeine prior to adenosine imaging

Time frame: Assess at time of lab sample results obtained