Nelfinavir and M8 Drug-level Monitoring in HIV-1 Infection

Inclusion Criteria: * Antiretroviral naive or currently taking a nelfinavir containing HAART regimen where nelfinavir is the first protease inhibitor * Patients willing to comply with the protocol * Age greater than or equal to 18 years * Virologically successful if already on an established regimen Exclusion Criteria: * Prior use of a protease inhibitor exclusive of nelfinavir * Required use or concomitant use of drugs that may interact with or are contraindicated with nelfinavir * Use of immunomodulators or vaccines for HIV disease * Intercurrent illness at the time of enrollment that, in the clinician's judgement, could influence the HIV RNA concentration * Baseline ALT levels greater than five times the upper limit of normal