Acid-Associated Heartburn Symptoms and Dose of Esomeprazole

Inclusion Criteria: * Males and non-lactating females, aged 18 to 75 years, inclusive, with the ability to understand English and provide written informed consent * A history of heartburn for at least 6 months * A history of prior positive relief of heartburn symptoms from antacids or acid suppressive therapy * A positive esophageal acid perfusion test * At least 3 days of 'moderate' severity heartburn over the previous 7 days * No use of any acid suppression therapy (PPI, H2RA, etc.) within 14 days of randomization Exclusion Criteria: * A history of gastric or esophageal surgery * H. pylori positive * A history of endoscopy -verified erosive esophagitis within the 16 weeks prior to randomization * Currently taking higher than the standard approved proton pump inhibitor doses * Historical evidence of a number of other GI, cardiovascular, pulmonary, liver, kidney, pancreatic, cerebral vascular diseases, organ transplant, or a condition requiring surgery.