Intensified Chemotherapy in CRC After Resection of Liver Metastases

Inclusion Criteria: * Histologically proven adenocarcinoma of the colon or rectum without previous resection, or clinically asymptomatic (with or without stent) * Hepatic unresectable metastases R0: due to close vascular contact, or due to liver remaining mass less than 25 to 30 % of functional liver. * Not optimally resectable metastases * Extra-hepatic disease will be accepted in case of: asymptomatic primary tumour or tumor requiring no urgent surgery (in less than 3 months); three of less than three lung metastases (thoracic scan diameter less than 2 cm) and potentially respectable. * Synchronous and metachronous hepatic metastases * WHO performance status 0-1 * Adjuvant chemotherapy allowed, except oxaliplatin and irinotecan based combination. * No prior treatment of the liver metastases, whatever. * Life expectancy equal or more than 3 months Exclusion Criteria: \-