A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving

Phase 2CompletedNCT00208858

Emory University

Overview

The purpose of this study is to gather pilot data to determine feasibility of and guide the development of a larger clinical trial investigating the effects of topiramate as an adjunct to nicotine replacement therapy and behavioral counseling in smoking cessation treatment. It is hypothesized that topiramate will decrease nicotine craving and result in improved outcomes for smoking cessation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Conditions

Tobacco Use Disorder

Interventions

TopiramateDRUG

Eligibility

Sex: MALEMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male, between ages of 18-55 * Meets DSM-IV criteria for nicotine dependence * Smoke at least 20 cigarettes per day * Motivated to quit smoking Exclusion Criteria: * Serious or unstable medical conditions * Current psychiatric disorder requiring medication or treatment * Taking medication that create risk of interaction with study drug * Current participation in another smoking cessation treatment

Locations (1)

Atlanta VA Medical Center

Decatur, Georgia, United States

Data from ClinicalTrials.gov

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