Women scheduled for abdominal hysterectomy needs postoperative pain treatment, i.e. morphine. Unfortunately morphine has side-effect: nausea, vomiting, sedation and dizziness, which is unpleasant for the patients and sometimes keeps them at bed longer time than needed. We investigate in new combinations of analgesics for postoperative pain, hoping to minimize the need for morphine.
Combinations of paracetamol versus paracetamol + pregabalin versus paracetamol + pregabalin + dexamethasone is investigated. Primary outcome is 24 hours morphine usage.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
130
Comparing combinations of paracetamol + pregabalin 300 mg + dexamethasone 8 mg
Operations og Anæstesiologisk afd. Y, KAS Glostrup
Glostrup Municipality, Copenhagen, Denmark
Herning Centralsygehus
Herning, Denmark
The total amount of morphine needed postoperatively form 0 - 4 h, and 0 - 24 h, administered by the patient controlled pain treatment. (PCA)
Time frame: 0 - 24h
Pain Score (VAS) at rest and at mobilisation.
Time frame: 0 - 24h
Postoperative nausea and vomiting.
Time frame: 0 - 24h
Sedation.
Time frame: 0 - 24h
Dizziness.
Time frame: 0 - 24h
All measurements are taken at 2, 4 and 24 h postoperatively.
Time frame: 0 - 24h
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