Phase I/II Study of Taxotere,CDDP and 5-FU(TPF) in Pre-treated Pts With Metastatic Esophageal Cancer.

Inclusion Criteria: * Histologically confirmed metastatic or recurrent esophageal tumors with previous treatment for advanced disease.(Except for small cell carcinoma) * At least one measurable lesion according to the RECIST criteria. Minimum indicator lesion size: \> 10 mm measured by spiral CT or \>20mm measured by conventional techniques(Except for Phase I setting). * Patients aged between 20 and 75 years, inclusive, at the time of acquisition of informed consent * Patients with performance status(ECOG) 0 to 2 * Abnormal hematologic values (WBC ≥ 3.5 x 109/L, Hemoglobin ≥ 9.5g/dl, platelet count ≥ 100 x 109/L) * Creatinine clearance ≥ 60 ml/min, Serum cleatinine ≤ 1.5mg/dl * Serum bilirubin ≤ 1.5mg/dl. ALT, AST ≤ 2.5 x upper normal limit (or ≤ 3 x upper normal limit in the case of liver metastases) * Patients who have received 1cycle cancer therapy (radiotherapy, chemotherapy or chemoradiotherapy) given \> 4 weeks prior to the beginning of study therapy * Life expectancy ≥ 3 months * Patients who have given written informed consent to participate in this study Exclusion Criteria: * Patients with active multiple cancers; or even if the multiple cancers are metachronous, have a disease-free period of less than 5 years (but excluding cancer in situ and skin cancer) (Except for Phase I setting) * Serious, uncontrolled, concurrent infection(s) or illness(es) * Patients with no serious concurrent complications (such as heart disease, Intestinal pneumonia) * Patients with brain metastasis * Patients receiving continuous administration of steroids * Patients who have experienced serious drug allergy in the past * Patients with retention of body fluid(pleural effusion, ascites, pericardial effusion) necessitating treatment * Patients who are pregnant and lactating or hope to become pregnant during the study period * Patients with prior Taxan treatment (Paclitaxel, Docetaxel) * Patients with edema ≥ grade 2 * Others, patients judged by the investigator or subinvestigator to be inappropriate as subject