A Pharmacokinetic Evaluation Study in Healthy Volunteers

Inclusion Criteria: * Are current nonsmokers or previous smokers who have not smoked within 6 months and who do not have greater than or equal to a 10 pack-year history of tobacco use * Are within 20% of their ideal body weight * Are healthy on the basis of a pre-trial physical examination Exclusion Criteria: * History or suspicion of recent alcohol, barbiturate, amphetamine or narcotic abuse or a positive urine drug test at study screening * History of cardiac arrhythmias, any pathological abnormality on the ECG, bronchospasm, diabetes mellitus, thyrotoxicosis, Parkinsonism, asthma, COPD or cardiovascular disease significant drug allergy * Subject with a physical obstruction in the nose * Use of concomitant medication other than hormonal contraceptives and multi-vitamins * Subjects with a current upper respiratory illness or infection for the 2 weeks prior to screening or any chronic respiratory illness