Administration of Ketamine to Prevent the Post-operative Pain

Institut Bergonié230 enrolled

Overview

The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse effects. The purpose is to evaluate the analgesic effect of a receptor NMDA's antagonist ( ketamine)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

230

Conditions

Postoperative Pain Breast Cancer

Interventions

KetamineDRUG

Saline solutionDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion criteria: * Patients 18 years older * ASA class 1 or 2 * with surgery of breast cancer (mastectomy or tumorectomy) Exclusion criteria: .Kétamine hypersensitivity * Major psychiatric disorders * Major cardio-vascular disorders * Major neurologic disorders * Major ocular disorders * Morphine in pre-operative period

Locations (1)

Institut Bergonié - Centre Régional de Luttre Contre le Cancer de Bordeaux et du Sud Ouest

Bordeaux, France

Outcomes

Primary Outcomes

Morphine Consumption (First 48 Post-operative Hours)

Number of participants with at least one consumption of morphine within 48 hours following surgery.

Time frame: within 48 hours following surgery

Secondary Outcomes

Post-operative Pain

Count of participants with post-operative pain. Pain was measured using a Visual Analog Rating Scale (VAS), ranging from 0 (no pain) to 10 (pain). A VAS score \>= 4 wwas considered as "Pain". A VAS sore \<4 was considered as "No pain".

Time frame: 48 hours after surgery

Data from ClinicalTrials.gov

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