Combination Therapy (Provigil + Avonex) to Treat Cognitive Problems in MS

Inclusion Criteria: * Patients entering the study will: * Be taking Avonex * Have normal laboratory blood tests and EKG * Be complaining of attention problems to treating neurologist * Be English-speaking males and females between the ages of 25 and 60, inclusive \[If patient is female, she must * Be surgically sterile; or * Be 2 years postmenopausal; or * If of child-bearing potential, must be using a medically accepted method of birth control and agree to continue to use this method for the duration of the study (i.e., barrier method with spermicide, steroidal contraceptive \[oral, implanted, and Depo-Provera contraceptives must be used in conjunction with a barrier method\], IUD, or abstinence)\] * Have clinically definite RR MS with disease duration of less than 10 years * Have an EDSS score between 0 and 5.5 * Have corrected vision of no worse than 20/50 * Have between 10 and 20 years of education * Be cerebral-stimulant free for at least one week prior to Attention Screening * Be able to complete self-rating scales and cognitive assessment tools * Have provided written informed consent * To have performed at least one standard deviation below normative expectation on at least two of four measures in the attention screening evaluation Exclusion Criteria: * Patients entering the study will NOT: * A history of heart disease or liver dysfunction * Have abnormal EKG or laboratory blood work, * Have a history of psychosis * Be a significant risk of suicide * Be abusing alcohol (current and within last 2 years) * Be abusing controlled substances (current and within last 2 years) * Have any medical ailment which can produce fatigue, such as lupus, anemia or thyroid disease * Have any history of clinical deviation from normal ranges in the physical examination * Have an unstable medical disorder, or medical contraindication to the use of Provigil * Have any history of head injury, seizures, or neurological conditions involving the central nervous system other than RR MS * Have any disorder that may interfere with drug absorption, distribution, metabolism, or excretion, including gastrointestinal surgery * Be a pregnant or lactating female (any patient becoming pregnant during the study will be discontinued) * Have received any investigational product within 30 days of Cognitive Screening * Have upper extremity dysfunction that prohibits them from using a computer mouse writing with a pencil * Be colorblind