myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies

University Hospital, Rouen100 enrolled

Overview

The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care. Objective 1 : to develop and evaluate the diagnostic value of a dedicated DNA-array (myoARRAY) for adult-onset muscular diseases with focus on inflammatory myopathies. Objective 2 : to evaluate the diagnostic value of T cell repertoire (TcLand) analysis to distinguish different forms of inflammatory myopathies.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Polymyositis Dermatomyositis

Interventions

transcriptome analysisOTHER

transcriptome analysis from muscle biopsy

T cell repertoire analysisOTHER

blood T cell repertoire analysis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 76 Years

Medical Language ↔ Plain English

Inclusion Criteria: * indication of muscle biopsy for diagnostic purpose * written informed consent Exclusion Criteria: * vasculitis * coagulation disorder, impossibility to perform muscle biopsy

Locations (1)

University Hospital of Rouen

Rouen, Seine Maritime, France

Outcomes

Primary Outcomes

transcriptome

Time frame: at inclusion

Data from ClinicalTrials.gov

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