CPAP Versus Bilevel Pressure Support Ventilation in Cardiogenic Pulmonary Edema

University Hospital, Rouen

Overview

To evaluate whether bilevel positive airway pressure more rapidly improves ventilation than continuous positive airway pressure (CPAP) in patients with acute pulmonary edema. CPAP is delivered via a simple device connected to oxygen.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Severe Acute Cardiogenic Pulmonary Edema

Interventions

Boussignac CPAP - bilevel ventilation supportDEVICE

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 16 yrs, acute onset of severe respiratory distress, bilateral rales and typical findings of congestion on chest radiograph * breathing frequency of \> 30/min, SpO2 \>90%, use of accessory respiratory muscles

Outcomes

Primary Outcomes

Improvement in PaCO2 at the end of ventilation

Secondary Outcomes

Endotracheal intubation, myocardial infarction and mortality during the first 24 hours

Duration of the ventilation

Blood gases, vital signs

Time to transfer to medical ward

Time to hospital discharge

Easiness to use was evaluated by nurses

Patients operational tolerance

Complications of each ventilation mode

Data from ClinicalTrials.gov

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