TWIST Human Gene and Cleft Lips and Palates

University Hospital, Strasbourg, France45 enrolled

Overview

This study uses a sequence analysis for TWIST and other craniofacial development genes, among patients presenting with facial clefting.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Cleft Lip

Interventions

None: molecular genetics diagnosis procedure onlyOTHER

None: molecular genetics diagnosis procedure only

Eligibility

Sex: ALLMin age: 1 Month

Medical Language ↔ Plain English

Inclusion Criteria: Patients aged from 1 month to 18 years: * Parents agree to enrollment or patients, themselves, agree to enrollment when able to do so * Healthcare insurance holders * Display facial clefting Grown patients over 18 years of age: * Agree to enrollment * Display facial clefting * Healthcare insurance holders Exclusion Criteria: * Patients declining enrollment * Patients without healthcare insurance

Locations (4)

Centre d'Investigations Cliniques, Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Centre de Soins , d'Enseignement et de Recherche Dentaire (CESRD), Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Service de Chirurgie Infantile, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Service de Consultation de la Face, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Outcomes

Primary Outcomes

to show, among patients displaying facial clefting, the TWIST mutations and the mutation in genes involved with TWIST in craniofacial development

Time frame: Not relevant

Secondary Outcomes

to show, among patients displaying facial clefting and mutations in such genes, possible mutations in the same genes

Time frame: Not relevant

Data from ClinicalTrials.gov

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