L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function

University Hospital, Strasbourg, France30 enrolled

Overview

* exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction * cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation * to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Heart Transplantation

Interventions

12 g of L-arginine glutamate during 6 weeks twice a dayDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male (\> 18 years old) stable heart transplant recipient for at least 6 weeks * Stable treatment for at least 3 months * Sedentary people Exclusion Criteria: * Unstable cardiac pathology * Obesity (IMC \> 40) * Participation in another study in the last month * Chronic renal failure (creatinine clearance \< 20 ml/min) * Renal transplantation * Diabetes * Impossibility to practice exercise test * Nitrate therapy

Locations (3)

Institut de Physiologie

Strasbourg, France

Service de Chirurgie Vasculaire

Strasbourg, France

Service des Explorations Fonctionnelles Respiratoires et de l'Exercice

Strasbourg, France

Outcomes

Primary Outcomes

Maximal and sub maximal exercise capacity at the end of the 6 weeks L-arginine supplementation. Renal function at the end of the 6 weeks

Secondary Outcomes

No secondary effects

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.