This study is designed to test the hypothesis that salmeterol use, and not fluticasone use or the combination treatment with fluticasone and salmeterol, is associated with a greater number of sputum eosinophils following antigen challenge and, under these circumstances, the migrating peripheral blood eosinophils are less adherent.
An antigen challenge is when a participant inhales either cat, ragweed, or dust dander in increasing concentrations until their lung function drops 15 or 20 percent.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
36
salmeterol diskus 50 mcg twice per day
placebo diskus, fluticasone MDI 88 mcg twice per day
placebo diskus
University of Wisconsin
Madison, Wisconsin, United States
Sputum Eosinophils (EOS) 24 Hours Post Antigen Challenge
Sputum samples were collected from the participants. Cell counts were made from these samples after treatment with 0.1% dithiothreitol. Percentage of eosinophils were reported. Time frame measurement was 24 hours after the subject had an antigen challenge.
Time frame: Eosinophils are measured 24 hours after the subject has an antigen challenge
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