Intensity Modulated Radiation Therapy (IMRT) Radiotherapy for Treating Prostate Pelvic Nodes

University of Wisconsin, Madison30 enrolled

Overview

The purpose of this study is to examine the clinical feasibility and efficacy of uing IMRT to escalate the biologically effective dose to the pelvic lymph nodes in a short course of radiation therapy. An increased total and biologically effective dose will be delivered to the pelvic lymph nodes (56 Gy at 2 Gy/fraction). The prostate will receive standard "short course" IMRT of radiation (70 Gy at 2.5 Gy/fraction).

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Prostate Cancer

Interventions

radiotherapyRADIATION

prostate radiation to 70Gy; nodal radiation to 56Gy

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Prostate cancer stage T-T3 * Predicted risk of lymph node involvement \> 15% * Gleason \> 7 Exclusion Criteria: * Distance metastases * Use of anti-coagulant therapy

Locations (1)

University Of Wisconsin Hospital and Clinics

Madison, Wisconsin, United States

Outcomes

Primary Outcomes

Number of Participants Experiencing Expected Toxicities

Tolerances to high dose RT to Pelvic Lymph nodes in treatment of prostate cancer; measured by participants experiencing expected toxicities.

Time frame: Up to 5 years

Secondary Outcomes

To Evaluate Local Tumor Control and Biochemical Progression-free and Metastasis-free Survival

Clinically evaluate local tumor control and biochemical progression-free and metastasis-free survivals.

Time frame: 5 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.