Reproducibility of the Array-Based Comparative Genomic Hybridization (aCGH) System Using Whole Blood Samples

Inclusion Criteria: * Must be able to donate at least 10 mL of whole blood * Must be able to provide consent, or parental consent and patient assent (if applicable) * Must be currently followed as a patient of a genetic clinic or counselor at one of the recruiting sites * Must have at least one chromosomal change that is detectable by the GeneTrait CGH Microarray System DX as determined by karyotype and/or fluorescence in situ hybridization (FISH) analysis (within any of the 73 critical regions) Exclusion Criteria: * Unable to donate at least 10 mL of whole blood * Unable to provide consent, or parental consent and patient assent (if applicable) * Not currently followed as a patient of a genetic clinic or counselor at one of the recruiting sites * Does not have at least one chromosomal change that is detectable by the GeneTrait CGH Microarray System DX as determined by karyotype and/or FISH analysis (within any of the 73 critical regions)